In silico prediction of ARB resistance: A first step in creating personalized ARB therapy
S. D. Anderson, A. Tabassum, J. K. Yeon, G. Sharma, P. Santos, T. H. Soong, Y. W. Thu, I. Nies, T. Kurita, A. Chandler, A. Alsamarah, R.-S. Kanassatega, Y. Luo, W. M. Botello-Smith, B. T. Andresen
This study predicts ARB resistance by simulating how nsSNPs in the AT1R gene affect drug binding, achieving 60% accuracy in predicting resistance.
bioRxiv · Feb 12, 2020Pharmacology & Toxicology