G. Sharma

Nanodisc reconstitution and characterization of amyloid-β precursor protein C99

This study reconstitutes and characterizes the C99 domain of APP in nanodiscs using multiple biophysical methods.

Whole genome sequencing and comparative genomic studies of Priestia filamentosa JURBA-X for its drought-tolerance, plant-growth promotion, and fluorescent characteristics

This study sequenced and compared the genome of Priestia filamentosa JURBA-X, identifying its drought tolerance, plant growth promotion, and fluorescent properties linked to resistomycin production.

Effect of environmental conditions on the wing morphometric variation in Aedes aegypti (Diptera: Culicidae) in India

This study examines wing morphometric variation in Aedes aegypti across India, finding significant differences in wing size and shape related to geographic and environmental factors.

A Synthetic Cytotoxic T cell Platform for Rapidly Prototyping TCR Function

This paper introduces a synthetic cytotoxic T cell platform for rapidly prototyping TCR function, demonstrating successful antigen-specific responses and preservation of antigen-presenting cells.

Whole Genome Sequencing and Assembly of the House Sparrow, Passer domesticus

The paper provides a high-quality whole genome sequence and assembly for the house sparrow, Passer domesticus, which serves as a reference for comparative and population genomic studies.

Integrin-like adhesin CglD confers traction and stabilizes bacterial focal adhesions involved in myxobacterial gliding motility

The paper identifies CglD as a β-integrin-like adhesin in Myxococcus xanthus that stabilizes bacterial focal adhesions and enables gliding motility through mechanosensory and mechanotransductory functions.

Site-specific acetylation of polynucleotide kinase 3-phosphatase (PNKP) regulates its distinct role in DNA repair pathways

This study shows that acetylation of PNKP at K142 and K226 regulates its distinct roles in DNA repair pathways, with K142 involved in BER/SSBR and K226 in DSBR.

Rational engineering of an elevator-type metal transporter ZIP8 reveals a conditional selectivity filter critically involved in determining substrate specificity

This study rationally engineers ZIP8 to alter its substrate specificity, identifying a conditional selectivity filter that determines substrate preference based on transporter conformation.

An evolutionarily conserved strategy for ribosome binding and inhibition by β-coronavirus non-structural protein 1

This paper identifies conserved ribosome-binding mechanisms in β-coronavirus Nsp1 proteins and shows how a cis-acting RNA element modulates Nsp1 function.

Novel psilocin prodrugs with altered pharmacological properties as candidate therapies for treatment-resistant anxiety disorders

This paper identifies novel psilocin prodrugs with altered pharmacokinetics and reduced psychedelic effects, maintaining therapeutic benefits for anxiety disorders.

Factors influencing the detergent-free membrane protein isolation using synthetic nanodisc-forming polymers

This study evaluates the efficacy of inulin-based polymers in solubilizing E. coli membranes containing specific membrane proteins under various conditions.

Ex vivo primary liver sections recapitulate disease phenotype and therapeutic rescue for liver monogenic diseases

This study uses precision-cut liver sections from mice to model monogenic liver diseases and test gene therapy efficacy.

Leaf hydration status under drought is predominantly linked to stomatal regulation and leaf roll but not osmotic adjustment in Canadian hard red spring wheat (Triticum aestivum) cultivars

This study shows that Canadian hard red spring wheat cultivars maintain leaf hydration and yield through early leaf roll and rapid stomatal closure, not osmotic adjustment or isohydric behavior during drought.

CYCLODEXTRIN DERIVATIVE ENHANCES THE OPHTHALMIC DELIVERY OF POORLY SOLUBLE AZITHROMYCIN.

This paper develops an in situ gel formulation of azithromycin with sulfobutylether-β-cyclodextrin to improve ocular delivery and antimicrobial efficacy for treating bacterial conjunctivitis.

Bacterial outer-membrane polysaccharide export (OPX) proteins occupy three structural classes with selective β-barrel porin requirements for polymer secretion

The paper identifies three structural classes of bacterial OPX proteins and shows that some use β-barrel porins for polysaccharide secretion when they cannot span the outer membrane.

Systemic infection of SARS-CoV-2 in free ranging Leopard (Panthera pardus fusca) in India

The paper reports SARS-CoV-2 infection in a free-ranging Indian leopard, confirming Delta variant infection and highlighting the need for wildlife screening.

Country-wide genomic surveillance of SARS-CoV-2 strains

The paper analyzes the time lag in SARS-CoV-2 genomic submission across countries and highlights the need for faster data sharing to improve public health responses.

Phenotypic shifts of tumor associated macrophages and STAT3 mediated suppression of myeloid derived suppressor cells drive sensitization of HER2+ tumor immunity.

The paper uses single-cell RNA-sequencing to show entinostat shifts tumor microenvironment cell states, reducing immunosuppression and enhancing immune checkpoint inhibitor responses in HER2+ breast tumors.

Molecular forms of Anopheles subpictus s.l. and Anopheles sundaicus s.l. in the Indian subcontinent

The paper identifies and classifies molecular forms of Anopheles subpictus s.l. and Anopheles sundaicus s.l. in the Indian subcontinent using DNA sequencing and phylogenetic analysis.

CglB adhesins secreted at bacterial focal adhesions mediate gliding motility

The paper identifies CglB as a substratum-coupling protein secreted by the gliding complex in Myxococcus xanthus, revealing a mechanism for force transduction and a novel secretion process.

Recombinant T cell receptors specific for HLA-A*02:01-restricted neoepitopes containing KRAS codon 12 hotspot mutations

The paper identifies and characterizes T cell receptors specific for HLA-A*02:01-restricted KRAS codon 12 mutations in cancer, showing their reactivity and cytotoxic activity against tumor cells.

Modulation of bacterial multicellularity via spatiotemporal polysaccharide secretion

The paper shows that Myxococcus xanthus uses temporally and spatially controlled polysaccharide secretion to coordinate multicellular behaviors like swarm migration and biofilm formation.

In silico prediction of ARB resistance: A first step in creating personalized ARB therapy

This study predicts ARB resistance by simulating how nsSNPs in the AT1R gene affect drug binding, achieving 60% accuracy in predicting resistance.