A. Amado

Unpredictability of the fitness effects of antimicrobial resistance mutations across environments in Escherichia coli

This study shows that the fitness effects of antimicrobial resistance mutations vary widely across genetic backgrounds and environments in Escherichia coli, challenging assumptions about their predictability.

Ecological tradeoffs lead to complex evolutionary trajectories and sustained diversity on dynamic fitness landscapes

This study simulates eco-evolutionary dynamics on a dynamic fitness landscape incorporating ecological interactions, showing that ecological interactions can sustain diversity and coexistence of genotypes.

STUN: forward-time Simulation on TUnable fitNess landscapes in recombining populations

STUN simulates polygenic adaptation in recombining populations using fitness landscape models and provides a flexible tool for studying evolutionary dynamics.

Rapid adaptation of recombining populations on tunable fitness landscapes

This study simulates adaptation in recombining populations on tunable fitness landscapes, finding that recombination hinders movement through rugged landscapes and that epistasis and recombination interact to influence allele fixation.

Epistasis decreases with increasing antibiotic pressure but not temperature

The paper quantifies genotype-by-genotype-by-environment interactions in E. coli under varying antibiotic and temperature conditions, finding that epistasis decreases with higher antibiotic pressure but not temperature.

Ecological specialization under multidimensional tradeoffs

The paper develops a resource-based model to study ecological specialization under multiple tradeoffs and finds that outcomes depend on tradeoff curvature and resource availability.