The deacylase SIRT5 supports melanoma viability by regulating chromatin dynamics
W. Giblin, L. Bringman-Rodenbarger, A. H. Guo, S. Kumar, A. C. Monovich, A. M. Mostafa, M. E. Skinner, M. Azar, A. S. A. Mady, C. H. Chung, N. Kadambi, K.-A. Melong, H.-J. Lee, L. Zhang, P. Sajjakulnukit, , D. B. Lombard
This study identifies SIRT5 as essential for melanoma cell survival and tumor formation, showing it regulates chromatin dynamics and gene expression through histone modifications.
bioRxiv · Sep 7, 2020 · PreprintCancer Biology