Author

M. E. Skinner

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 2 Cancer Biology· 2 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:mouse· 4 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Assay:flow cytometry· 2 Organism:human· 2 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

D. B. Lombard· 3 shared A. H. Guo· 2 shared C. A. Lyssiotis· 2 shared E. K. Makowski· 2 shared H. L. Paulson· 2 shared H. Trzeciakiewicz· 2 shared J. M. Zupancic· 2 shared L. Zhang· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersCancer Biology

D. B. Lombard

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Author profile →

5 papers

Recent·Most cited

Flow cytometric isolation of drug-like conformational antibodies specific for amyloid fibrils

A. A. Desai, J. M. Zupancic, H. Trzeciakiewicz, J. E. Gerson, K. N. DuBois, M. E. Skinner, L. M. Sharkey, N. McArthur, S. P. Ferris, N. N. Bhatt, E. K. Makowski, M. D. Smith, H. Chen, J. Huang, C. Jerez, , P. M. Tessier

This paper describes a FACS method using quantum dots to isolate high-quality conformational antibodies against insoluble antigens like amyloid fibrils.

bioRxiv · Jul 4, 2023 · PreprintBioengineering

Quantitative flow cytometric selection of tau conformational nanobodies specific for pathological aggregates

J. M. Zupancic, M. D. Smith, H. Trzeciakiewicz, M. E. Skinner, S. P. Ferris, E. K. Makowski, M. J. Lucas, N. McArthur, R. S. Kane, H. L. Paulson, P. M. Tessier

This study selects conformational nanobodies specific for aggregated tau using flow cytometry, showing their utility in detecting tau aggregates in mouse and human samples.

bioRxiv · May 13, 2023 · PreprintBioengineering

Sirtuin 5 levels are limiting in preserving cardiac function and suppressing fibrosis in response to pressure overload

A. H. Guo, R. K. Baliira, M. E. Skinner, S. Kumar, A. Andren, L. Zhang, S. Michan, N. J. Davis, M. W. Maccani, S. Day, D. A. Sinclair, C. A. Lyssiotis, A. B. Stein, D. B. Lombard

This study shows that overexpressing SIRT5 protects against cardiac dysfunction and fibrosis in response to pressure overload in mice.

bioRxiv · Jun 15, 2021Pathology

Canagliflozin increases adenoma burden in female APCMin/+ mice

J. L. Korfhage, M. E. Skinner, J. Basu, J. K. Greenson, R. A. Miller, D. B. Lombard

This study shows that canagliflozin increases adenoma burden in female APCMin/+ mice, suggesting complex, cell-non-autonomous mechanisms and sex differences in drug effects.

bioRxiv · Mar 27, 2021Cancer Biology

The deacylase SIRT5 supports melanoma viability by regulating chromatin dynamics

W. Giblin, L. Bringman-Rodenbarger, A. H. Guo, S. Kumar, A. C. Monovich, A. M. Mostafa, M. E. Skinner, M. Azar, A. S. A. Mady, C. H. Chung, N. Kadambi, K.-A. Melong, H.-J. Lee, L. Zhang, P. Sajjakulnukit, , D. B. Lombard

This study identifies SIRT5 as essential for melanoma cell survival and tumor formation, showing it regulates chromatin dynamics and gene expression through histone modifications.

bioRxiv · Sep 7, 2020 · PreprintCancer Biology