C. A. Lyssiotis

Glutamine catabolism supports amino acid biosynthesis and suppresses the integrated stress response to promote photoreceptor survival

Sulfide oxidation promotes hypoxic angiogenesis and neovascularization

This study shows that sulfide oxidation via SQOR promotes hypoxic angiogenesis and neovascularization by reprogramming metabolic pathways in endothelial cells.

Targeting PIKfyve-driven lipid homeostasis as a metabolic vulnerability in pancreatic cancer

This study identifies PIKfyve as a targetable vulnerability in pancreatic cancer by showing its role in lipid metabolism and synthetic lethality with KRAS-MAPK inhibitors.

Epigenetic reprogramming of autophagy leads to uncovering a novel therapeutic target for mutant IDH1 astrocytomas

This study identifies autophagy as a critical survival pathway in mIDH1 gliomas and shows that inhibiting autophagy enhances radiosensitivity and tumor regression in preclinical models.

Development of an orally bioavailable mSWI/SNF ATPase degrader and acquired mechanisms of resistance in prostate cancer

This paper develops an orally bioavailable PROTAC degrader of mSWI/SNF ATPases for prostate cancer and identifies resistance mechanisms through long-term treatment.

BRD4-mediated epigenetic regulation of endoplasmic reticulum-mitochondria contact sites is governed by the mitochondrial complex III

The paper identifies fedratinib as a drug that increases endoplasmic reticulum-mitochondria contact sites by inhibiting BRD4, revealing a novel epigenetic pathway linking ERMCS to cellular metabolism.

Type I interferon governs immunometabolic checkpoints that coordinate inflammation during Staphylococcal infection

This paper shows type I interferon coordinates immunometabolic checkpoints during Staphylococcal infection by regulating metabolic and inflammatory programs in macrophages.

Glucose-6-phosphate dehydrogenase deficiency accelerates pancreatic acinar-to-ductal metaplasia

This study shows that G6PD deficiency accelerates pancreatic acinar-to-ductal metaplasia by enhancing NADPH production for ROS management, highlighting a metabolic role in early tumorigenesis.

H2S preconditioning induces long-lived perturbations in O2 metabolism

This study shows that H2S preconditioning causes long-lasting changes in O2 metabolism, including increased P50(O2) and metabolic memory effects lasting up to 24-48 hours.

Tissue-Specific Dependence of Th1 Cells on the Amino Acid Transporter SLC38A1 in Inflammation

This study identifies tissue- and subset-specific roles of SLC38A1 in Th1 cell function during inflammation, showing its importance in EAE and IBD but not lung inflammation.

De novo purine metabolism is a metabolic vulnerability of cancers with low p16 expression

This study identifies de novo purine metabolism as a vulnerability in cancers with low p16 expression, showing sensitivity to anti-folate drugs like methotrexate.

GTP signaling links metabolism, DNA repair, and responses to genotoxic stress

This study identifies a GTP-mediated signaling pathway linking metabolism to DNA repair and resistance to genotoxic stress in glioblastoma and non-malignant cells.

Subset-specific mitochondrial and DNA damage shapes T cell responses to fever and inflammation

The paper shows that fever increases inflammatory activity in CD4+ T cells but causes mitochondrial dysfunction and DNA damage specifically in Th1 cells, leading to p53-dependent apoptosis to prevent mutations.

PINK1 supports colorectal cancer growth by regulating the labile iron pool.

This study shows PINK1 supports colorectal cancer growth by regulating the labile iron pool through mitophagy and ferritinophagy.

Cardiolipin coordinates inflammatory metabolic reprogramming through regulation of Complex II assembly and stability

The paper shows cardiolipin regulates Complex II assembly and stability in macrophages, linking it to inflammatory metabolic reprogramming.

Arginase 1 is a key driver of immune suppression in pancreatic cancer

This study shows that Arginase 1 suppresses immune responses in pancreatic cancer by inhibiting T cell activation, and targeting it enhances immunotherapy effectiveness.

Microenvironmental Ammonia Enhances T cell Exhaustion in Colorectal Cancer

This study shows that ammonia accumulation in the colorectal cancer microenvironment promotes T cell exhaustion and treatment resistance, and that reducing ammonia improves immunotherapy efficacy.

Increased glucose availability sensitizes pancreatic cancer to chemotherapy

This study shows that high glucose levels increase the effectiveness of chemotherapy in pancreatic cancer by reducing glutathione biosynthesis, which enhances oxidative stress in cancer cells.

Therapeutic targeting of differentiation state-dependent metabolic vulnerabilities in DIPG

This study identifies metabolic vulnerabilities in DIPG subtypes and shows that targeting these vulnerabilities with specific drugs can extend survival in preclinical models.

NetrinG1+ cancer-associated fibroblasts generate unique extracellular vesicles that support the survival of pancreatic cancer cells under nutritional stress

This study identifies NetrinG1+ cancer-associated fibroblasts that produce extracellular vesicles supporting pancreatic cancer cell survival under nutrient stress.

Glutamine metabolism enables NKT cell homeostasis and function through the AMPK-mTORC1 signaling axis

OXPHOS Promotes Apoptotic Resistance and Persistence in TH17 cells

This study shows that OXPHOS enhances TH17 cell survival and persistence by promoting mitochondrial fitness and anti-apoptotic markers.

Multi-omic Characterization of Pancreatic Cancer-Associated Macrophage Polarization Reveals Deregulated Metabolic Programs Driven by the GMCSF-PI3K Pathway

This study identifies metabolic markers and pathways in pancreatic tumor-associated macrophages using multi-omic analysis and in vitro models.

A redox cycle with complex II promotes sulfide quinone oxidoreductase dependent H2S oxidation

The paper identifies a redox cycle involving complex II and SQOR that sustains H2S oxidation when complex IV is inhibited, improving H2S clearance in cells exposed to microbiota-derived H2S.

Extrinsic KRAS signaling shapes the pancreatic microenvironment through fibroblast reprogramming.

This study shows that extrinsic KRAS signaling reprograms pancreatic fibroblasts to create an inflammatory microenvironment that supports tumor growth.

Sirtuin 5 levels are limiting in preserving cardiac function and suppressing fibrosis in response to pressure overload

This study shows that overexpressing SIRT5 protects against cardiac dysfunction and fibrosis in response to pressure overload in mice.

Nutrient profiling reveals extracellular uridine as a fuel for pancreatic cancer through uridine phosphorylase 1

This study identifies uridine as a novel nutrient for pancreatic cancer cells through uridine phosphorylase 1, showing its role in survival and metabolism under glucose deprivation.

Multi-dimensional analyses identify genes of high priority for pancreatic cancer research

The paper identifies consistently expressed genes in pancreatic ductal adenocarcinoma (PDAC) to prioritize therapeutic targets and biomarkers.

Human norovirus infection of primary B cells triggers immune activation in vitro

This study shows human norovirus infects primary B cells, induces functional changes, and the NS1 protein affects B cell proliferation and metabolism in vitro.

Microbiota metabolic exchange is critical for colorectal cancer redox homeostasis and growth

This study identifies reuterin as a microbial metabolite that suppresses colorectal cancer growth by altering redox balance and inducing cell death.