Author

A. H. Guo

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Approach:experimental assay· 3 Research Focus:chromatin & epigenetic regulation· 2 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

D. B. Lombard· 3 shared C. A. Lyssiotis· 2 shared L. Zhang· 2 shared M. E. Skinner· 2 shared S. Kumar· 2 shared Z. Nikolovska-Coleska· 2 shared A. Andea· 1 shared A. Andren· 1 shared

Activity by Year

2019-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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3 shared papersPathology

D. B. Lombard

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Author profile →

3 papers

Recent·Most cited

Sirtuin 5 levels are limiting in preserving cardiac function and suppressing fibrosis in response to pressure overload

A. H. Guo, R. K. Baliira, M. E. Skinner, S. Kumar, A. Andren, L. Zhang, S. Michan, N. J. Davis, M. W. Maccani, S. Day, D. A. Sinclair, C. A. Lyssiotis, A. B. Stein, D. B. Lombard

This study shows that overexpressing SIRT5 protects against cardiac dysfunction and fibrosis in response to pressure overload in mice.

bioRxiv · Jun 15, 2021Pathology

The deacylase SIRT5 supports melanoma viability by regulating chromatin dynamics

W. Giblin, L. Bringman-Rodenbarger, A. H. Guo, S. Kumar, A. C. Monovich, A. M. Mostafa, M. E. Skinner, M. Azar, A. S. A. Mady, C. H. Chung, N. Kadambi, K.-A. Melong, H.-J. Lee, L. Zhang, P. Sajjakulnukit, , D. B. Lombard

This study identifies SIRT5 as essential for melanoma cell survival and tumor formation, showing it regulates chromatin dynamics and gene expression through histone modifications.

bioRxiv · Sep 7, 2020 · PreprintCancer Biology

High throughput small molecule screening reveals NRF2-dependent and -independent pathways of cellular stress resistance

D. B. Lombard, W. Kohler, A. H. Guo, C. Gendron, M. Han, W. Ding, Y. Lyu, X. Li, X. Shi, Z. Nikolovska-Coleska, Y. Duan, T. Girke, A.-L. Hsu, S. D. Pletcher, R. S. Miller

This study identifies small molecules that induce cellular stress resistance against paraquat, cadmium, and methyl methanesulfonate, with some compounds activating Nrf2 signaling and others triggering inflammatory and AMPK pathways.

bioRxiv · Sep 22, 2019Cell Biology