Author

A. Awazu

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 7 Cell Biology· 1 Zoology· 1

Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 5 Approach:biophysical modeling· 3 Assay:DNA methylation· 2 Approach:mechanistic / dynamical model· 2 Organism:mouse· 2 Research Focus:protein folding & dynamics· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

M. Fujii· 3 shared T. Kameda· 2 shared Y. Togashi· 2 shared D. Takemoto· 1 shared D.-Q. Ding· 1 shared F. Hayashi· 1 shared H. Nishimori· 1 shared H. Yamashita· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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3 shared papersBiophysics

M. Fujii

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Author profile →

9 papers

Recent·Most cited

Possibilities of skin coat color-dependent risks and risk factors of squamous cell carcinoma and deafness of domestic cats inferred via RNA-seq data

A. Awazu, D. Takemoto, K. Watanabe, N. Sakamoto

The paper analyzes RNA-seq data from domestic cats with different coat colors to explore links between coat color-related gene expression and risks of squamous cell carcinoma and deafness.

bioRxiv · Jul 17, 2023Zoology

Mathematical model of nuclear speckle morphology

S. Wakao, N. Saitoh, A. Awazu

The paper develops a coarse-grained molecular dynamics model of nuclear speckles to simulate and predict morphological changes based on interactions among SON, SRRM2, MALAT1, and pre-mRNA.

bioRxiv · Jan 12, 2023 · PreprintCell Biology

Formation Of Small-World Network Containing Module Networks In Globally And Locally Coupled Map System With Changes In Global Connection With Time Delay Effects

T. Nakanishi, A. Awazu

This study investigates network formation in coupled map systems with global and local connections, finding that time delay effects and local interactions promote small-world networks with module structures similar to neural networks.

bioRxiv · Nov 13, 2022Biophysics

Mathematical model of chromosomal dynamics during DNA double strand break repair in budding yeast

S. Nakahata, M. Fujii, A. Awazu

The paper develops mathematical models to simulate chromosomal dynamics during DNA double-strand break repair in budding yeast, identifying histone degradation and repair protein rigid structures as key factors in relocating damaged loci to the nuclear periphery.

bioRxiv · Feb 1, 2022Biophysics

Epigenetic-structural changes in X chromosomes promote Xic pairing during early differentiation from mouse embryonic stem cells

T. Komoto, M. Fujii, A. Awazu

The paper develops a molecular dynamics model to study how epigenetic-structural changes in X chromosomes drive Xic pairing during early differentiation of mouse embryonic stem cells.

bioRxiv · Oct 25, 2021Biophysics

Structural Dynamics of DNA Depending on Methylation Pattern

T. Kameda, M. M. Suzuki, A. Awazu, Y. Togashi

This study uses molecular dynamics simulations to investigate how DNA methylation patterns affect DNA structure and dynamics, revealing changes in local flexibility and overall geometry.

bioRxiv · Jun 29, 2020Biophysics

Affinity of rhodopsin to raft enables the aligned oligomer formation from dimers: Coarse-grained molecular dynamics simulation of disk membranes

Y. Kaneshige, F. Hayashi, K. Morigaki, H. Yamashita, M. Fujii, A. Awazu

This study uses coarse-grained molecular dynamics simulations to show that raftophilic H1/H8 rhodopsin dimers form aligned rows stabilized by lipid rafts, enhancing phototransduction efficiency.

bioRxiv · Nov 21, 2019Biophysics

Histone Tail Dynamics in Partially Disassembled Nucleosomes During Chromatin Remodeling

T. Kameda, A. Awazu, Y. Togashi

This study uses molecular dynamics simulations to analyze the dynamics of partially disassembled nucleosomes, finding that DNA deformation is more pronounced in nucleosomes lacking H2A/H2B compared to those lacking H3/H4.

bioRxiv · May 9, 2019Biophysics

Turning and twisting motion of chromosomes as an accelerating force to align homologous chromosomes during meiosis

K. Takao, K. Takamiya, D.-Q. Ding, T. Haraguchi, Y. Hiraoka, H. Nishimori, A. Awazu

This study models nuclear oscillatory movements during meiosis and finds that chromosomal torsional turning, driven by directional reversals, contributes to aligning homologous chromosomes.

bioRxiv · Dec 12, 2018Biophysics