Y. Hiraoka

Proteasome-dependent Orc6 removal from chromatin upon S-phase entry safeguards against MCM reloading and tetraploidy

The paper shows that proteasome-dependent removal of Orc6 from chromatin during S-phase prevents abnormal MCM reloading and tetraploidy in human cells.

Nuclear membrane protein Bqt4 maintains nuclear envelope integrity by recruiting phosphatidic acid

This study identifies Bqt4 as an inner nuclear membrane protein that recruits phosphatidic acid to maintain nuclear envelope integrity in fission yeast.

Retrovirus-derived RTL9 plays an important role in innate antifungal immunity in the eutherian brain

The paper shows RTL9, a retrovirus-derived gene, is essential for microglial antifungal immunity by degrading fungal zymosan in the brain.

A ubiquitin-proteasome pathway degrades the inner nuclear membrane protein Bqt4 to maintain nuclear membrane homeostasis

The paper identifies the ubiquitin-proteasome pathway as a mechanism for degrading the inner nuclear membrane protein Bqt4 to maintain nuclear membrane homeostasis.

Retrovirus-derived acquired genes, RTL5 and RTL6, are novel constituents of the innate immune system in the eutherian brain.

This study identifies RTL5 and RTL6 as retrovirus-derived genes involved in microglial innate immune responses against pathogens in the eutherian brain.

Rec8 cohesin-mediated axis-loop chromatin architecture is required for meiotic recombination

This study shows that Rec8 cohesin forms axis-loop structures in fission yeast meiosis, which are necessary for LinE assembly and meiotic recombination, independent of sister chromatid cohesion.

Chromatin loading of MCM hexamers is associated with di-/tri-methylation of histone H4K20 toward S phase entry

This study investigates MCM hexamer states during the cell cycle in human cells and links their formation to histone H4K20 methylation levels, showing that di/trimethyl-H4K20 correlates with double MCM hexamer formation.

Microtubule inhibitors identified through non-biased screening enhance DNA transfection efficiency by delaying p62-dependent ubiquitin recruitment

The Linear Element is a Stable Structure Along the Chromosome Axis in Fission Yeast

This study uses live cell imaging to characterize the stable structure and dynamics of LinEs in fission yeast during meiosis.

Asymmetrical localization of Nup107-160 subcomplex components within the nuclear pore complex in fission yeast

This study reveals asymmetrical localization of the Nup107-160 subcomplex in fission yeast, contrasting with symmetrical localization in other organisms, and shows its necessity for cell cycle progression.

Turning and twisting motion of chromosomes as an accelerating force to align homologous chromosomes during meiosis

This study models nuclear oscillatory movements during meiosis and finds that chromosomal torsional turning, driven by directional reversals, contributes to aligning homologous chromosomes.

Exportin Crm1 is repurposed as a docking protein to generate microtubule organizing centers at the nuclear pore

The paper identifies how Mto1 docks at nuclear pore complexes via Crm1 and Nup146 to form non-centrosomal MTOCs.

Compositionally distinct nuclear pore complexes of functionally distinct dimorphic nuclei in ciliate Tetrahymena

The paper identifies compositionally distinct nuclear pore complexes in the macronucleus and micronucleus of Tetrahymena, highlighting functional specialization through unique nucleoporin localization.