Pharmacological elevation of cellular dihydrosphingomyelin provides a novel antiviral strategy against West Nile virus infection
N. Jimenez de Oya, A. San-Felix, M. Casasampere, A. B. Blazquez, P. Mingo-Casas, E. Escribano-Romero, E. Calvo-Pinilla, T. Poderoso, J. Casas, J.-C. Saiz, M. J. Perez-Perez, M. A. Martin-Acebes
This study identifies polyphenols that inhibit West Nile virus by altering sphingolipid metabolism, specifically increasing dihydrosphingomyelin levels.
bioRxiv · Dec 19, 2022 · PreprintMicrobiology