Molecular Mechanism of Hyperactivation Conferred by a Truncated TRPA1 Disease Mutant Suggests New Gating Insights
A. Bali, S. P. Schaefer, I. Trier, A. L. Zhang, L. Kabeche, C. E. Paulsen
This paper investigates the R919* TRPA1 mutant, showing it is functionally inactive alone but enhances agonist sensitivity when co-expressed with wild-type TRPA1, revealing a novel mechanism of channel hyperactivation.
bioRxiv · Jan 5, 2022 · PreprintBiochemistry