First passage time analysis of spatial mutation patterns reveals evolutionary dynamics of pre-existing resistance in colorectal cancer
M. J. Haughey, A. Bassolas, S. Sousa, A.-M. Baker, T. A. Graham, V. Nicosia, W. Huang
This paper introduces a first passage time analysis framework to quantify spatial mutation patterns in colorectal cancer, revealing sub-clonal dynamics and replicative advantages of mutant cells.
bioRxiv · Feb 22, 2022 · PreprintCancer Biology