S. Sousa

Streptococcus pneumoniae infection of lung epithelial cells induces internalization of surface GPI-anchored proteins through pneumolysin-mediated activation of host Rho GTPases

This study shows that pneumolysin from Streptococcus pneumoniae causes internalization of GPI-anchored proteins in lung epithelial cells via Rho GTPase activation, reducing cell death and membrane damage.

The widely used cymoxanil fungicide impairs respiration in Saccharomyces cerevisiae via cytochrome c oxidase inhibition

This study investigates how the fungicide cymoxanil impairs respiration in yeast by inhibiting cytochrome c oxidase.

Molecular properties of RmlT, a wall teichoic acid rhamnosyltransferase that modulates virulence in Listeria monocytogenes.

This study characterizes RmlT, a rhamnosyltransferase in L. monocytogenes, showing its role in WTA rhamnosylation and its potential as a target for antimicrobial strategies.

Modulation of the functional interfaces between retroviral intasomes and the human nucleosome

The paper develops an alphaLISA assay to study intasome-nucleosome interactions, identifies compounds that modulate this interaction, and shows their antiviral effects against PFV and HIV-1.

First passage time analysis of spatial mutation patterns reveals evolutionary dynamics of pre-existing resistance in colorectal cancer

This paper introduces a first passage time analysis framework to quantify spatial mutation patterns in colorectal cancer, revealing sub-clonal dynamics and replicative advantages of mutant cells.

Stabilin-1 plays a protective role against Listeria monocytogenes infection through the regulation of cytokine and chemokine production and immune cell recruitment

This study shows that Stabilin-1 regulates cytokine/chemokine production and immune cell recruitment during Listeria monocytogenes infection, promoting bacterial clearance but being downregulated by the pathogen.

In silico, in vitro and in cellulo models for monitoring SARS-CoV-2 spike/human ACE2 complex, viral entry and cell fusion

Src-dependent NM2A tyrosine-phosphorylation regulates actomyosin dynamics

This study identifies Src-dependent NM2A tyrosine-phosphorylation at residue 158 as a regulator of actomyosin dynamics and cell responses to bacterial infection.