Divergent modulation of dopaminergic neurons by hypocretin/orexin receptors-1 and -2 shapes dopaminergic cell activity and socio-emotional behavior
Tzanoulinou S., S. Astori, Laura Clara Grandi, F. Gullo, Richie Kalusivikako, Rai S., Limorenko G., Mehdi Tafti, A. Becchetti, A. Vassalli
This study investigates the distinct roles of OX1R and OX2R in modulating dopaminergic neuron activity and socio-emotional behaviors in mice, revealing differential impacts on anxiety, hyperactivity, and learning.
bioRxiv · Feb 14, 2025Neuroscience