Degradation of Photoreceptor Outer Segments by the Retinal Pigment Epithelium Requires Pigment Epithelium-derived Factor Receptor (PEDF-R)
J. Bullock, F. Polato, , M. Abu-Asab, A. Bernardo-Colon, E. Aflaki, M.-P. Agbaga, S. P. Becerra
This study shows that PEDF-R is essential for efficient degradation of photoreceptor outer segments by RPE cells, as its absence impairs lipid metabolism and rhodopsin breakdown during phagocytosis.
bioRxiv · Jan 1, 2021Biochemistry