In vivo-Active Soluble Epoxide Hydrolase-targeting PROTACs with Improved Potency and Stability
K. Nakane, C. Morisseau, P. D. Dowker-Key, G. Benitez, J. T. Aguilan, E. Nagai, S. Sidoli, B. D. Hammock, A. Bettaieb, K. Shinoda, S. Kitamura
This paper develops next-generation sEH-targeting PROTACs with improved potency and stability, showing effective degradation in mouse tissues.
bioRxiv · Jul 23, 2024Biochemistry