The replication of the human respiratory syncytial virus in a T cell line has multiple ineffective steps
R. de Souza Cardoso, A. C. L. Coelho, B. L. S. de Jesus, B. C. Vitti, J. d. P. Souza, R. M. M. Viana, M. C. Pontelli, T. Murakami, A. M. Ventura, A. Ono, E. Arruda
This study shows that HRSV infection of CD4+ T cells is inefficient compared to epithelial cells, with reduced fusion, lower protein production, and altered viral trafficking.
bioRxiv · Dec 28, 2020Microbiology