Cancer BiologybioRxiv
Combining CRISPR/Cas9 mutagenesis and a small-molecule inhibitor to probe the function of MELK in cancer
C. J. Giuliano, A. Lin, J. C. Smith…·J. M. Sheltzer
This study uses CRISPR/Cas9 and a MELK inhibitor to show that MELK knockout cancer cells grow normally, suggesting anti-MELK therapies may not be effective as monotherapies.
DOI 10.7554/elife.32838