Single-cell immune repertoire and transcriptome sequencing reveals that clonally expanded and transcriptionally distinct lymphocytes populate the aged central nervous system in mice
A. Yermanos, D. Neumeier, I. Sandu, M. Borsa, A. C. Waindok, D. Merkler, A. Oxenius, S. T. Reddy
This study uses single-cell sequencing to show that aged mouse brains have clonally expanded and transcriptionally distinct lymphocytes, potentially contributing to neuroinflammation.
bioRxiv · May 4, 2020Immunology