M. Borsa

Inheritance of old mitochondria controls early CD8+ T cell fate commitment and is regulated by autophagy

This study shows that autophagy regulates asymmetric inheritance of old mitochondria in CD8+ T cells, which influences their metabolic state and memory potential.

Asparagine availability controls B cell homeostasis

The paper shows asparagine metabolism is critical for B cell function and germinal centre homeostasis, with Asn deprivation impairing survival, proliferation, and immune responses.

Asymmetric cell division safeguards memory CD8 T cell development

This study shows that asymmetric cell division supports memory CD8 T cell development under strong TCR stimulation but not weak stimulation.

Mapping of the autophagosomal degradome identifies IL-7Rα as key cargo in proliferating CD4+ T-cells

The paper identifies IL-7Rα as a key autophagosomal cargo in proliferating CD4+ T cells using a transgenic mouse model with LC3 proximity labeling.

Adipocyte autophagy limits gut inflammation by controlling oxylipin levels

The paper shows that adipocyte autophagy reduces gut inflammation by regulating oxylipin levels through NRF2-mediated Ephx1 upregulation.

Single-cell immune repertoire and transcriptome sequencing reveals that clonally expanded and transcriptionally distinct lymphocytes populate the aged central nervous system in mice

This study uses single-cell sequencing to show that aged mouse brains have clonally expanded and transcriptionally distinct lymphocytes, potentially contributing to neuroinflammation.

Profiling virus-specific Tcf1+ T cell repertoires during acute and chronic viral infection

The paper analyzes Tcf1+ and Tcf1- T cell repertoires during acute and chronic LCMV infection, finding they are not clonally distinct and show minor differences in repertoire parameters.