I. Sandu

Single-cell immune repertoire sequencing of B and T cells in murine models of infection and autoimmunity

The paper profiles clonal selection of B and T cells in murine models of infection and autoimmunity using single-cell sequencing, linking repertoire features to cell phenotypes.

Generation of a single-cell B cell atlas of antibody repertoires and transcriptomes to identify signatures associated with antigen-specificity

The paper generates a single-cell B cell atlas to link antibody repertoires, transcriptomes, and antigen specificity in murine immunization models.

Clonally expanded virus-specific CD8 T cells acquire diverse transcriptional phenotypes during acute, chronic, and latent infections

This study examines clonal expansion and transcriptional diversity in virus-specific CD8 T cells across different infection stages using single-cell sequencing and a new bioinformatic tool.

Nanoconfinement of Microvilli Alters Gene Expression and Boosts T cell Activation

This study shows that nanoporous surfaces enhance T cell activation by altering gene expression and promoting microvilli formation through size-dependent protein segregation.

Single-cell sequencing reveals clonally expanded plasma cells during chronic viral infection produce virus-specific and cross-reactive antibodies

Locally confined IFNγ production by CD4+ T cells provides niches for murine cytomegalovirus replication in the salivary gland

This study shows that CD4+ T cells produce IFNγ locally in clusters near MCMV infection foci in salivary glands, enabling regional protection while allowing continued viral replication.

Fate trajectories of CD8+ T cells in chronic LCMV infection

This study uses scRNA-seq to analyze CD8+ T cell fate trajectories during chronic LCMV infection, identifying a branching point where cells commit to exhausted or memory-like lineages.

Single-cell immune repertoire and transcriptome sequencing reveals that clonally expanded and transcriptionally distinct lymphocytes populate the aged central nervous system in mice

This study uses single-cell sequencing to show that aged mouse brains have clonally expanded and transcriptionally distinct lymphocytes, potentially contributing to neuroinflammation.

Profiling virus-specific Tcf1+ T cell repertoires during acute and chronic viral infection

The paper analyzes Tcf1+ and Tcf1- T cell repertoires during acute and chronic LCMV infection, finding they are not clonally distinct and show minor differences in repertoire parameters.