A. Chattaraj

Measurement of solubility product in a model condensate reveals the interplay of small oligomerization and self-association

The paper measures the solubility product in a model condensate to predict phase separation, finding that small oligomers and homotypic interactions influence the threshold.

Multi-condensate state as a functional strategy to optimize the cell signaling output

The paper demonstrates that multiple biomolecular condensates can optimize cell signaling output by maximizing actin polymerization through an optimal number of condensates.

Separation of sticker-spacer energetics governs the coalescence of metastable condensates

This study simulates condensate coalescence using metadynamics and finds that sticker-spacer polymers undergo kinetic arrest or entropy-driven fusion depending on sticker exchange dynamics and density.

The maximum solubility product marks the threshold for condensation of multivalent biomolecules

This study shows how the solubility product marks the threshold for condensation of multivalent biomolecules using simulations and theoretical analysis.

Solubility product constant directs the formation of biomolecular condensates

The paper establishes that the solubility product constant (Ksp) dictates the formation of biomolecular condensates through liquid-liquid phase separation.

The interplay of structural and cellular biophysics controls clustering of multivalent molecules

The paper uses computational models to study how molecular structure and cellular organization influence clustering of multivalent molecules, revealing mechanisms that affect cluster size and phase separation potential.