Author

L. M. Loew

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 8 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 5 Approach:experimental assay· 4 Approach:deep learning· 3 Assay:imaging· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Organism:mouse· 1

Frequent Co-Authors

A. Chattaraj· 4 shared M. L. Blinov· 2 shared A. D. Schuyler· 1 shared A. E. Cowan· 1 shared B. J. Mayer· 1 shared C. Acker· 1 shared D. F. Wong· 1 shared D. L. Thorek· 1 shared

Activity by Year

2017-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 6 mutual co-author links

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4 shared papersBiophysics

A. Chattaraj

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Author profile →

9 papers

Recent·Most cited

Measurement of solubility product in a model condensate reveals the interplay of small oligomerization and self-association

A. Chattaraj, Z. Baltaci, B. J. Mayer, L. M. Loew, J. A. Ditlev

The paper measures the solubility product in a model condensate to predict phase separation, finding that small oligomers and homotypic interactions influence the threshold.

bioRxiv · Jan 23, 2024 · PreprintBiophysics

Beyond analytic solution: analysis of FRAP experiments by spatial simulation of the forward problem

A. E. Cowan, L. M. Loew

The paper demonstrates using spatial numerical simulations with Virtual Cell software to analyze FRAP experiments in complex geometries where analytic solutions are inadequate.

bioRxiv · Mar 5, 2023Biophysics

The maximum solubility product marks the threshold for condensation of multivalent biomolecules

A. Chattaraj, L. M. Loew

This study shows how the solubility product marks the threshold for condensation of multivalent biomolecules using simulations and theoretical analysis.

bioRxiv · Oct 4, 2022Biophysics

Solubility product constant directs the formation of biomolecular condensates

A. Chattaraj, M. L. Blinov, L. M. Loew

The paper establishes that the solubility product constant (Ksp) dictates the formation of biomolecular condensates through liquid-liquid phase separation.

bioRxiv · Dec 26, 2020 · PreprintBiophysics

The interplay of structural and cellular biophysics controls clustering of multivalent molecules

A. Chattaraj, M. Youngstrom, L. M. Loew

The paper uses computational models to study how molecular structure and cellular organization influence clustering of multivalent molecules, revealing mechanisms that affect cluster size and phase separation potential.

bioRxiv · Dec 26, 2018Biophysics

Tethered Bichromophoric Fluorophore Quencher Voltage Sensitive Dyes

P. Yan, C. Acker, L. M. Loew

This paper develops tethered bichromophoric fluorophore quencher (TBFQ) dyes for improved voltage sensing, achieving higher sensitivity and faster response kinetics than existing fluorescent voltage sensors.

bioRxiv · Nov 19, 2018Biophysics

Voltage-sensitive dye delivery through the blood brain barrier using adenosine receptor agonist Regadenoson

R. W. Pak, J. Kang, H. Valentine, L. M. Loew, D. L. Thorek, E. M. Boctor, D. F. Wong, J. U. Kang

The paper demonstrates the feasibility of delivering a voltage-sensitive dye to brain tissue using Regadenoson to enhance BBB permeability, as shown by increased fluorescence signal residence time.

bioRxiv · May 7, 2018Bioengineering

mol2sphere: Spherical Decomposition of Multi-Domain Molecules for Visualization and Coarse Grained Spatial Modeling

J. Masison, P. J. Michalski, L. M. Loew, A. D. Schuyler

mol2sphere transforms macromolecular structures into linked spheres for visualization and coarse-grained modeling of multi-domain proteins.

bioRxiv · Jan 31, 2018Biophysics

Compartmental and spatial rule-based modeling with Virtual Cell (VCell)

M. L. Blinov, J. C. Schaff, D. Vasilescu, I. I. Moraru, J. E. Bloom, L. M. Loew

This paper extends the Virtual Cell framework to support compartmental and spatial rule-based modeling, enabling simulations of molecular interactions in defined geometries.

bioRxiv · Aug 3, 2017Biophysics