A. Chauffour

Minimal effective dose of oral bedaquiline and activity of a long acting formulation of bedaquiline in the murine model of leprosy

This study determines the minimal effective dose of oral bedaquiline and evaluates the efficacy of a long-acting injectable formulation in a murine model of leprosy, finding that the MED is 3.3 mg/kg and the injectable form is less effective than oral administration.

Q203 containing fully intermittent oral regimens exhibited high sterilizing activity against Mycobacterium ulcerans in mice

The paper evaluates the bactericidal and sterilizing activity of Q203 in intermittent oral regimens against Mycobacterium ulcerans in mice, finding high sterilizing activity with combined regimens.