Spatial transcriptomics reveal pitfalls and opportunities for the detection of rare high-plasticity breast cancer subtypes
A. Coutant, V. Cockenpot, L. Muller, C. Degletagne, R. Pommier, L. Tonon, M. Ardin, M.-C. Michallet, C. Caux, M. Laurent, A.-P. Morel, P. Saintigny, A. Puisieux, M. Ouzounova, P. Martinez
The paper uses spatial transcriptomics to identify specific markers for rare high-plasticity breast cancer subtypes, showing that bulk expression signatures are limited by stromal contamination.
bioRxiv · Apr 24, 2023Cancer Biology