Author

A. Cuevas-Navarro

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Assay:proteomics· 2 Approach:biophysical modeling· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

A. Cheng· 2 shared F. McCormick· 2 shared P. Castel· 2 shared R. Van· 2 shared A. G. Stephen· 1 shared A. Urisman· 1 shared D. K. Simanshu· 1 shared M. J. Sale· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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2 shared papersBiochemistry

A. Cheng

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2 papers

Recent·Most cited

Ras-dependent RAF-MAPK hyperactivation by pathogenic RIT1 is a therapeutic target in Noonan syndrome-associated cardiac hypertrophy

A. Cuevas-Navarro, M. Wagner, R. Van, M. Swain, M. R. Allison, A. Cheng, S. Messing, D. K. Simanshu, M. J. Sale, F. McCormick, A. G. Stephen, P. Castel

This study identifies how pathogenic RIT1 mutations drive RAF-MAPK hyperactivation in Noonan syndrome, showing MEK inhibition can alleviate cardiac hypertrophy in a mouse model.

bioRxiv · Nov 2, 2022Biochemistry

The RAS GTPase RIT1 compromises mitotic fidelity through spindle assembly checkpoint suppression

A. Cuevas-Navarro, R. Van, A. Cheng, A. Urisman, P. Castel, F. McCormick

This study shows that RIT1, a Ras GTPase, suppresses the spindle assembly checkpoint, leading to mitotic errors and chromosome segregation defects.

bioRxiv · Nov 17, 2020Biochemistry