Typhoid toxin hijacks Wnt5a to potentiate TGFβ-mediated senescence and Salmonella infection
M. ElGhazaly, M. O. Collins, A. E. Ibler, D. Humphreys
The paper identifies Wnt5a as a secreted ligand that enhances TGFβ signaling and promotes senescence, which Salmonella exploits to increase infection susceptibility.
bioRxiv · Oct 5, 2022 · PreprintCell Biology