Pharmacological inhibition of nonsense-mediated RNA decay augments HLA class I-mediated presentation of neoepitopes in MSI CRC
J. P. Becker, D. Helm, M. Rettel, F. Stein, A. Hernandez-Sanchez, K. Urban, J. Gebert, M. Kloor, G. Neu-Yilik, M. von Knebel Doeberitz, M. W. Hentze, A. E. Kulozik
The paper shows that inhibiting nonsense-mediated RNA decay increases HLA class I presentation of neoepitopes from frameshift mutations in MSI colorectal cancer.
bioRxiv · Oct 13, 2020Cancer Biology