The acidic domain of the hepatitis C virus NS4A protein is required for viral assembly and envelopment through interactions with the viral E1 glycoprotein
This study identifies the role of NS4A's acidic domain in HCV assembly and envelopment by interacting with E1 glycoprotein, showing that mutations disrupt RNA incorporation into infectious virions.
bioRxiv · Jun 18, 2018Microbiology