Author

S. M. Horner

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 5 Microbiology· 3 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Research Focus:host-pathogen & immune response· 8 Organism:human· 5 Assay:metagenomics· 3 Assay:proteomics· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 1

Frequent Co-Authors

N. S. Gokhale· 4 shared M. Park· 3 shared D. C. Beachboard· 2 shared D. L. Snider· 2 shared G. D. Williams· 2 shared A. B. R. McIntyre· 1 shared A. E. Roder· 1 shared A. Oberst· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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4 shared papersImmunology

N. S. Gokhale

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Cellular RNA interacts with MAVS to promote antiviral signaling

N. S. Gokhale, K. Somfleth, M. G. Thompson, R. K. Sam, D. M. Marciniak, L. H. Chu, M. Park, S. Dvorkin, A. Oberst, S. M. Horner, S.-E. Ong, M. Gale, R. Savan

The paper shows that cellular RNA interacts with MAVS to scaffold signaling proteins and promote antiviral signaling by facilitating IRF3 phosphorylation.

bioRxiv · Sep 25, 2023 · PreprintImmunology

Structure-first identification of conserved RNA elements that regulate dengue virus genome architecture and replication.

M. A. Boerneke, N. S. Gokhale, S. M. Horner, K. M. Weeks

The paper identifies conserved RNA structures in dengue virus genomes that regulate replication and fitness, revealing their importance in viral function and potential as antiviral targets.

bioRxiv · Oct 10, 2022Biochemistry

WTAP targets the METTL3 m6A-methyltransferase complex to cytoplasmic hepatitis C virus RNA to regulate infection

M. T. Sacco, K. M. Bland, S. M. Horner

This paper shows WTAP recruits METTL3 to HCV RNA in the cytoplasm to regulate m6A modification and virion production, independent of nuclear localization.

bioRxiv · Jun 27, 2022Microbiology

Signaling from the RNA sensor RIG-I is regulated by ufmylation

D. L. Snider, M. Park, K. A. Murphy, D. C. Beachboard, S. M. Horner

This paper shows that ufmylation, mediated by UFL1, promotes RIG-I signaling by facilitating its interaction with 14-3-3ε and MAVS, enhancing IFN induction during RNA virus infection.

bioRxiv · Oct 26, 2021Immunology

Post-Transcriptional Regulation of Antiviral Gene Expression by N6-Methyladenosine

M. J. McFadden, A. B. R. McIntyre, H. Mourelatos, N. S. Abell, N. S. Gokhale, H. Ipas, B. Xhemalce, C. E. Mason, S. M. Horner

This study identifies N6-methyladenosine (m6A) as a post-transcriptional regulator of IFN-stimulated gene (ISG) translation during the type I IFN response, enhancing antiviral activity.

bioRxiv · Aug 5, 2020Immunology

The mRNA cap 2'O methyltransferase CMTR1 regulates the expression of certain interferon-stimulated genes

G. D. Williams, N. S. Gokhale, D. L. Snider, S. M. Horner

This study shows that CMTR1, an ISG, promotes the protein expression of specific ISGs involved in the antiviral response by preventing IFIT1 from inhibiting translation of mRNAs lacking cap 2O methylation.

bioRxiv · Mar 5, 2020Immunology

Hepatitis C virus infection is inhibited by a non-canonical antiviral signaling pathway targeted by NS3-NS4A

C. Vazquez, C. Y. Tan, S. M. Horner

This paper identifies a non-canonical antiviral signaling pathway involving Riplet and IRF3 that is inhibited by the HCV NS3-NS4A protease, revealing a new mechanism of immune evasion.

bioRxiv · May 2, 2019Microbiology

RAB1B interacts with TRAF3 to promote antiviral innate immunity

D. C. Beachboard, M. Park, M. Vijayan, D. J. Fernando, G. D. Williams, S. M. Horner

This study identifies RAB1B as a regulator of TRAF3 that enhances antiviral innate immunity by promoting the formation of signaling complexes in response to viral RNA.

bioRxiv · Feb 5, 2019Immunology

The acidic domain of the hepatitis C virus NS4A protein is required for viral assembly and envelopment through interactions with the viral E1 glycoprotein

A. E. Roder, S. M. Horner

This study identifies the role of NS4A's acidic domain in HCV assembly and envelopment by interacting with E1 glycoprotein, showing that mutations disrupt RNA incorporation into infectious virions.

bioRxiv · Jun 18, 2018Microbiology