Directed evolution of Escherichia coli with lower-than natural plasmid mutation rates
D. E. Deatherage, D. Leon, A. E. Rodriguez, S. K. Omar, J. E. Barrick
This study develops a directed evolution method to reduce plasmid mutation rates in E. coli, identifying mutations that improve genetic stability without compromising growth or expression.
bioRxiv · May 6, 2018Evolutionary Biology