Author

D. Leon

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 2

Signature Assays, Organisms & Methods

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Organism:E. coli· 2 Approach:experimental assay· 2 Assay:whole-genome sequencing· 2 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:genome assembly· 1

Frequent Co-Authors

J. E. Barrick· 2 shared A. E. Rodriguez· 1 shared D. E. Deatherage· 1 shared E. M. Quandt· 1 shared S. D'Alton· 1 shared S. K. Omar· 1 shared

Activity by Year

2018-2018 · peak 2/yr

Co-Author Collaboration Network

6 top collaborators · 9 mutual co-author links

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2 shared papersEvolutionary Biology

J. E. Barrick

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2 papers

Recent·Most cited

Directed evolution of Escherichia coli with lower-than natural plasmid mutation rates

D. E. Deatherage, D. Leon, A. E. Rodriguez, S. K. Omar, J. E. Barrick

This study develops a directed evolution method to reduce plasmid mutation rates in E. coli, identifying mutations that improve genetic stability without compromising growth or expression.

bioRxiv · May 6, 2018Evolutionary Biology

An evolutionary innovation is contingent on maintaining adaptive potential until competition subsides

D. Leon, S. D'Alton, E. M. Quandt, J. E. Barrick

The paper investigates the evolutionary conditions that enabled an E. coli population to develop citrate utilization, finding that maintaining genetic potential and reduced adaptation rates were critical.

bioRxiv · Jan 17, 2018Evolutionary Biology