Peripheral Inflammation Limits Serotonin Neuron Signaling Capacity via Serotonergic IL-1R1 to Reduce Neuronal Excitability and Enhance Serotonin Clearance
P. A. Gajewski, H. Iwamoto, Alaina N Tillman, Z. Filliben, A. E. Walsh, Nicole L. Baganz, Matthew James Robson, M. Zapata, Ning Quan, Randy Blakely
This study identifies how peripheral inflammation reduces serotonin neuron signaling through IL-1R1-mediated pathways, decreasing neuronal excitability and increasing serotonin clearance.
bioRxiv · Oct 13, 2025 · PreprintNeuroscience