Randy Blakely

Peripheral Inflammation Limits Serotonin Neuron Signaling Capacity via Serotonergic IL-1R1 to Reduce Neuronal Excitability and Enhance Serotonin Clearance

This study identifies how peripheral inflammation reduces serotonin neuron signaling through IL-1R1-mediated pathways, decreasing neuronal excitability and increasing serotonin clearance.

Kappa Opioid Receptor Antagonism Restores Phosphorylation, Trafficking and Behavior induced by a Disease Associated Dopamine Transporter Variant

This study shows that KOR antagonism restores phosphorylation, trafficking, and behavior in a mouse model with a disease-associated DAT variant.

Assigning Targetable Pathways to Transdiagnostic Subgroups Across Neurodevelopmental Disorders

The paper identifies molecular pathways associated with neurodevelopmental disorder subgroups using neuroimaging data from mice and humans.

Glial swip-10 expression controls systemic mitochondrial function, oxidative stress, and neuronal viability via copper ion homeostasis

This paper identifies swip-10's role in systemic copper homeostasis in C. elegans, linking it to mitochondrial function, oxidative stress, and neurodegeneration.

Disruptive mutations in the serotonin transporter associate serotonin dysfunction with treatment-resistant affective disorder

The paper identifies two disruptive SERT variants in treatment-resistant affective disorder patients and shows they cause partial loss-of-function, with one variant responsive to pharmacochaperoning.

Serotonin in the orbitofrontal cortex enhances cognitive flexibility

This study shows that serotonin release from the dorsal raphe nuclei to the orbitofrontal cortex enhances reversal learning by increasing neuronal excitability and synaptic plasticity.

DAT Val559 Mice Exhibit Compulsive Behavior Under Devalued Reward Conditions Accompanied by Cellular and Pharmacological Changes

Disrupted choline clearance and sustained acetylcholine release in vivo by a common choline transporter coding variant associated with poor attentional control in humans

This study shows that a common choline transporter variant reduces choline clearance and sustained acetylcholine release in mice, linking it to attentional deficits in humans.

Sex and Circuit Specific Dopamine Transporter Regulation Underlies Unique Behavioral Trajectories of Functional SLC6A3 Coding Variation

The paper investigates sex-specific effects of a dopamine transporter variant on behavior and identifies sex-dependent circuit-specific regulation of dopamine signaling.

Repetitive mild concussion in subjects with a vulnerable cholinergic system: lasting cholinergic-attentional impairments in CHT+/- mice.

This study shows that mice with reduced cholinergic capacity experience severe, lasting attention impairments after repeated mild concussions, suggesting similar risks in humans with vulnerable cholinergic systems.