RNA binding and HEPN nuclease activation are decoupled in CRISPR-Cas13a
A. Tambe, A. East-Seletsky, G. J. Knott, J. A. Doudna, M. R. O'Connell
This study shows that RNA binding and nuclease activation in CRISPR-Cas13a are separate processes, with distinct requirements for guide-target base pairing.
bioRxiv · Apr 16, 2018Biochemistry