Regulatory networks driving expression of genes critical for glioblastoma are controlled by the transcription factor c-Jun and the pre-existing epigenetic modifications.
A.-J. Roura, P. Szadkowska, K. Poleszak, M. J. Dabrowski, A. Ellert-Miklaszewska, K. Wojnicki, I. A. Ciechomska, K. Stepniak, B. Kaminska, B. Wojtas
The paper identifies c-Jun as a key transcription factor regulating genes critical for glioblastoma, with DNA methylation modulating its activity in GBM cells.
bioRxiv · Jul 18, 2022Cancer Biology