B. Kaminska

Deep Learning Glioma Grading with the Tumor Microenvironment Analysis Protocol for A Comprehensive Learning, Discovering, and Quantifying Microenvironmental Features

This paper develops a deep learning model for glioma grading using a tumor microenvironment analysis protocol, achieving 0.85 accuracy on a small, imbalanced dataset with single-stained biopsies.

H2A.Z histone variants facilitate HDACi-dependent removal of H3.3K27M mutant protein in paediatric high-grade glioma cells

This study shows HDAC inhibitors reduce H3.3K27M protein levels in glioma cells, with H2A.Z facilitating this effect, suggesting a potential therapeutic strategy for DIPG.

Comprehensive analysis of the transcription factor REST regulatory networks in IDH-mutant and IDH-wild type glioma

This study identifies differences in REST regulatory networks between IDH-mutant and IDH-wild type gliomas, highlighting distinct gene expression control mechanisms.

Regulatory networks driving expression of genes critical for glioblastoma are controlled by the transcription factor c-Jun and the pre-existing epigenetic modifications.

The paper identifies c-Jun as a key transcription factor regulating genes critical for glioblastoma, with DNA methylation modulating its activity in GBM cells.

Hypoxia-mediated regulation of DDX5 through decreased chromatin accessibility and post-translational targeting restricts R-loop accumulation

The paper shows hypoxia reduces DDX5 expression by decreasing chromatin accessibility and post-translational targeting, which limits R-loop accumulation in cancer cells.

ApoE4 disrupts interaction of sortilin with fatty acid-binding protein 7 essential to promote lipid signaling

The paper identifies how apoE4 disrupts sortilin-FABP7 interactions, impairing lipid signaling and contributing to Alzheimer's disease pathology.

Epigenetic regulation of differentially expressed genes between various glioma types

The paper integrates epigenetic and transcriptomic data to identify gene regulatory networks and chromatin organization differences between low and high grade gliomas.

The novel, recurrent mutation in the TOP2A gene results in the enhanced topoisomerase activity and transcription deregulation in glioblastoma

The paper identifies a novel TOP2A mutation in glioblastomas that enhances DNA binding and transcriptional activity, correlating with poorer patient survival.

Single-cell RNA sequencing reveals functional heterogeneity and sex differences of glioma-associated brain macrophages

This study uses scRNA-seq to identify functional heterogeneity and sex differences in myeloid cells in gliomas.

Mapping chromatin accessibility and active regulatory elements reveals new pathological mechanisms in human gliomas

The paper maps chromatin accessibility and regulatory elements in human gliomas to identify new epigenetic mechanisms driving cancer progression.