Author

K. Poleszak

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1

Frequent Co-Authors

A.-J. Roura· 2 shared B. Kaminska· 2 shared B. Wojtas· 2 shared P. Szadkowska· 2 shared A. Ellert-Miklaszewska· 1 shared A. Koziarski· 1 shared A. Marchel· 1 shared A. Styk· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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2 shared papersCancer Biology

A.-J. Roura

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Author profile →

2 papers

Recent·Most cited

Regulatory networks driving expression of genes critical for glioblastoma are controlled by the transcription factor c-Jun and the pre-existing epigenetic modifications.

A.-J. Roura, P. Szadkowska, K. Poleszak, M. J. Dabrowski, A. Ellert-Miklaszewska, K. Wojnicki, I. A. Ciechomska, K. Stepniak, B. Kaminska, B. Wojtas

The paper identifies c-Jun as a key transcription factor regulating genes critical for glioblastoma, with DNA methylation modulating its activity in GBM cells.

bioRxiv · Jul 18, 2022Cancer Biology

The novel, recurrent mutation in the TOP2A gene results in the enhanced topoisomerase activity and transcription deregulation in glioblastoma

B. Gielniewski, K. Poleszak, A.-J. Roura, P. Szadkowska, S. K. Krol, R. Guzik, P. Wiechecka, M. Maleszewska, B. Kaza, A. Marchel, T. Czernicki, A. Koziarski, G. Zielinski, A. Styk, M. Kawecki, , B. Kaminska

The paper identifies a novel TOP2A mutation in glioblastomas that enhances DNA binding and transcriptional activity, correlating with poorer patient survival.

bioRxiv · Jun 17, 2020 · PreprintCancer Biology