Author

P. Szadkowska

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

B. Kaminska· 3 shared A.-J. Roura· 2 shared B. Gielniewski· 2 shared B. Kaza· 2 shared B. Wojtas· 2 shared K. Poleszak· 2 shared K. Wojnicki· 2 shared A. Ellert-Miklaszewska· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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3 shared papersCancer Biology

B. Kaminska

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3 papers

Recent·Most cited

H2A.Z histone variants facilitate HDACi-dependent removal of H3.3K27M mutant protein in paediatric high-grade glioma cells

K. B. Leszczynska, A. Pereira de Freitas, C. Jayaprakash, M. Dzwigonska, K. Wojnicki, B. Gielniewski, P. Szadkowska, B. Kaza, M. K. Ciolkowski, J. Trubicka, W. Grajkowska, B. Kaminska, J. Mieczkowski

This study shows HDAC inhibitors reduce H3.3K27M protein levels in glioma cells, with H2A.Z facilitating this effect, suggesting a potential therapeutic strategy for DIPG.

bioRxiv · May 15, 2023Cancer Biology

Regulatory networks driving expression of genes critical for glioblastoma are controlled by the transcription factor c-Jun and the pre-existing epigenetic modifications.

A.-J. Roura, P. Szadkowska, K. Poleszak, M. J. Dabrowski, A. Ellert-Miklaszewska, K. Wojnicki, I. A. Ciechomska, K. Stepniak, B. Kaminska, B. Wojtas

The paper identifies c-Jun as a key transcription factor regulating genes critical for glioblastoma, with DNA methylation modulating its activity in GBM cells.

bioRxiv · Jul 18, 2022Cancer Biology

The novel, recurrent mutation in the TOP2A gene results in the enhanced topoisomerase activity and transcription deregulation in glioblastoma

B. Gielniewski, K. Poleszak, A.-J. Roura, P. Szadkowska, S. K. Krol, R. Guzik, P. Wiechecka, M. Maleszewska, B. Kaza, A. Marchel, T. Czernicki, A. Koziarski, G. Zielinski, A. Styk, M. Kawecki, , B. Kaminska

The paper identifies a novel TOP2A mutation in glioblastomas that enhances DNA binding and transcriptional activity, correlating with poorer patient survival.

bioRxiv · Jun 17, 2020 · PreprintCancer Biology