The absence of the autoimmune regulator gene (AIRE) impairs the three-dimensional structure of medullary thymic epithelial cell spheroids
A. C. Monteleone-Cassiano, J. A. Dernowsek, R. S. Mascarenhas, A. F. Assis, D. Pitol, J. M. Issa, E. A. Donadi, G. A. Passos
This study shows that AIRE deficiency disrupts mTEC spheroid 3D structure and alters adhesion gene regulation.
bioRxiv · Aug 11, 2021Immunology