Epidermis derived lactate promotes sterile inflammation by inducing metabolic rewiring in macrophages.
U. Ayyangar, A. Karkhanis, H. Tay, A. F. B. Afandi, O. Bhattacharjee, S. H. Lee, J. Chan, S. Raghavan
The paper shows that epidermis-derived lactate promotes sterile inflammation by inducing metabolic changes in macrophages that support their effector functions.
bioRxiv · Jul 29, 2022 · PreprintCell Biology