S. H. Lee

Targeting phosphatase DUSP22 ameliorates skeletal muscle wasting via Akt independent JNK-FOXO3a repression

This study identifies DUSP22 as a novel target for preventing skeletal muscle wasting by repressing the JNK-FOXO3a pathway independently of Akt.

Modular Phoneme Processing in Human Superior Temporal Gyrus

The paper identifies modular organization in human superior temporal gyrus for phoneme processing using high-density micro-arrays.

Spatial dissection of cellular heterogeneity and functional crosstalk in the tumor microenvironments of gastric cancers

This study uses spatial transcriptomics to analyze gastric cancer tumor microenvironments, identifying subtypes and functional interactions between cell types that correlate with clinical outcomes.

Genome-wide exploration of metabolic-based pyrethroid resistance mechanism in Helicoverpa armigera

This study identifies CYP3 subfamily gene variants and differential expression of detoxification enzymes as key factors in deltamethrin resistance in Helicoverpa armigera, rather than target site mutations.

The role of positively charged small biomolecules in the aggregation of hyperphosphorylated tau in Alzheimer's disease

This study identifies electrostatic interactions between hyperphosphorylated tau and polyamines as crucial for tau aggregation in Alzheimer's disease and observes the transition from aggregates to fibrils.

Genetic and transcriptomic analysis of hyphal constriction based on a novel assay method in the rice blast fungus

The paper introduces an in vitro assay to study hyphal constriction in Magnaporthe oryzae, identifying transcriptional changes and a potential histone modification role in this process.

Balance-directed protein engineering of IsPETase enhances both PET hydrolysis activity and thermostability

This study engineers IsPETase to balance PET hydrolysis activity and thermostability, resulting in a variant that outperforms existing variants in depolymerization efficiency.

Discovery and biosynthesis of imidazolium antibiotics from a probiotic Bacillus licheniformis

The paper identifies a novel imidazolium antibiotic from Bacillus licheniformis and proposes its biosynthetic pathway through various experimental methods.

Epidermis derived lactate promotes sterile inflammation by inducing metabolic rewiring in macrophages.

The paper shows that epidermis-derived lactate promotes sterile inflammation by inducing metabolic changes in macrophages that support their effector functions.

Complement receptor C5aR1 signaling in sensory neuron-associated macrophages drives neuropathic pain

This study identifies C5aR1 signaling in sensory neuron-associated macrophages as a driver of neuropathic pain and shows it can be inhibited to reduce pain.

Laser particle barcoding for multi-pass high-dimensional flow cytometry

This paper introduces multi-pass flow cytometry using laser particle barcoding to enable high-dimensional single-cell analysis with reduced spectral overlap and simplified panel design.

Molecular mechanics underlying flat-to-round membrane budding in live secretory cells

The paper identifies actin filaments and dynamin as key forces mediating non-coated membrane budding in live cells, revealing mechanisms that transform flat membranes into vesicles.

Inadvertent Transfer of Murine VL30 Retrotransposons to CAR-T Cells.

This study shows that murine VL30 retrotransposons can be inadvertently transferred to CAR-T cells via γ-retroviral vectors, raising biosafety concerns.

EFHD1 ablation reduces cardiac mitoflash activation and protects cardiomyocytes from ischemia.

This study shows that EFHD1 deletion reduces mitochondrial Ca2+ overload and ROS production, protecting cardiomyocytes from ischemia-induced injury.

Highly specific chimeric DNA-RNA guided genome editing with enhanced CRISPR-Cas12a system

The paper enhances CRISPR-Cas12a system specificity and efficiency using a chimeric DNA-RNA guide, achieving 7.41 and 7.60 times improvements respectively.

Yap/Taz-Activated Tert-Expressing Acinar Cells Are Required for Pancreatic Regeneration

This study identifies Tert+ acinar cells as critical for pancreatic regeneration, showing their activation by Yap/Taz and their role in tissue repair.

Immersive virtual prism adaptation therapy with depth sensing camera: A feasibility study with functional near infrared spectroscopy in healthy adults

This study tests virtual prism adaptation therapy using a depth-sensing camera and fNIRS in healthy adults to assess behavioral and cortical changes during adaptation phases.

High Content and High Throughout Phenotypic Assay for the Hourly Resolution of the Malaria Parasite Erythrocytic Cycle

This paper introduces a high-content, high-throughput phenotypic assay for studying the erythrocytic cycle of malaria parasites with hourly resolution.

Sex differences in bile acid homeostasis and excretion underlie the disparity in liver cancer incidence between males and females.

This study identifies sex-specific bile acid metabolism differences that protect female livers from liver cancer and suggests targeting bile acid excretion as a therapeutic strategy.

The role of dermis resident macrophages and their interaction with neutrophils in the early establishment of Leishmania major infection transmitted by sand fly bite

This study investigates how dermis resident macrophages and neutrophils interact during early Leishmania major infection transmitted by sand fly bite, revealing the role of phagocytosis and receptor tyrosine kinases in infection outcomes.

Core-periphery structure in mutualistic networks: an epitaph for nestedness?

The paper reviews 419 studies on mutualistic networks and argues that core-periphery structure is more relevant than nestedness for describing ecological network topology, providing code for its calculation in R.

Protective effect of agmatine against cisplatin-induced apoptosis in an auditory cell line

This study evaluates agmatine's protective effect against cisplatin-induced apoptosis in HEI-OC1 auditory cells, showing reduced BAX and caspase-3 activity.

Enhancement of Target Specificity of CRISPR-Cas12a by Using a Chimeric DNA-RNA Guide

This study enhances CRISPR-Cas12a specificity by using a chimeric DNA-RNA guide, reducing off-target mutations in genome editing.

Feasibility of real-time in vivo 89Zr-DFO-labeled CAR T-cell trafficking using PET imaging

This paper demonstrates the feasibility of using PET imaging to track 89Zr-DFO-labeled CAR T-cells in vivo, showing their distribution and migration over time.

Dual activity of PNGM-1, a metallo-β-lactamase and tRNase Z, pinpoints the evolutionary origin of subclass B3 metallo-β-lactamases

This paper identifies PNGM-1, a dual-activity enzyme with metallo-β-lactamase and tRNase Z functions, and shows it evolved from tRNase Z, providing insights into the origin of subclass B3 metallo-β-lactamases.

Metagenomic 16S rRNA gene sequencing survey of Borrelia species in Irish samples of Ixodes ricinus ticks

The paper surveys Borrelia species in Irish Ixodes ricinus ticks using 16S rRNA gene sequencing to identify infection rates and species diversity.

CRISPR Cas9 searches for a protospacer adjacent motif by one-dimensional diffusion

This study uses smFRET to show Cas9 searches for PAM sequences via one-dimensional diffusion, competing with 3D diffusion for efficient target binding.

TumorFusions: an integrative resource for reporting cancer-associated transcript fusions in 33 tumor types

The paper reports cancer-associated transcript fusions in 33 tumor types using TCGA data and provides a resource for accessing the results.