Sensing soluble uric acid by Naip1-Nlrp3 platform
T. T. Braga, M. R. Davanso, D. Mendes, T. A. Souza, A. F. de Brito, M. C. Cruz, M. I. Hiyane, D. S. de Lima, V. Nunes, J. d. F. Giarola, D. E. P. Souto, T. Prochnicki, M. Lauterbach, S. M. P. Biscaia, R. A. de Freitas, , N. O. S. Camara
The paper investigates how soluble uric acid is sensed by the Naip1-Nlrp3 inflammasome platform in murine macrophages and shows its role in IL-1β production and inflammation.
bioRxiv · May 15, 2020Immunology