A subtle structural modification of a synthetic cannabinoid receptor agonist drastically increases its efficacy at the CB1 receptor
H. Yano, R. Chitsazi, C. Lucaj, P. Tran, A. F. Hoffman, M. H. Baumann, C. R. Lupica, L. Shi
This study identifies a structural modification in a synthetic cannabinoid receptor agonist that significantly increases its efficacy at the CB1 receptor, with implications for monitoring illicit drug risks.
bioRxiv · Jun 10, 2023Pharmacology & Toxicology