H. Yano

Linkers in bitopic agonists shape bias profile among transducers for the dopamine D2 and D3 receptors

The paper analyzes bitopic ligands for dopamine D2 and D3 receptors, showing that linker structure and stereochemistry significantly influence transducer bias profiles.

Nationwide genome surveillance of carbapenem-resistant Pseudomonas aeruginosa in Japan

This study analyzes genome sequences and antimicrobial resistance patterns of carbapenem-resistant Pseudomonas aeruginosa isolates from Japan, revealing genetic diversity and lower multidrug resistance prevalence compared to other regions.

Characterization of Gαs and Gαolf activation by catechol and non-catechol dopamine D1 receptor agonists

This study evaluates how different dopamine D1 receptor agonists activate Gαs and Gαolf, revealing region-specific pharmacological profiles with implications for targeted drug development.

Wistar rats raised in an affectionate environment display lifesaving-like behaviors while distinguishing life from death

The study shows that Wistar rats raised in an affectionate environment display lifesaving-like behaviors, suggesting life valuation is not human-specific.

A subtle structural modification of a synthetic cannabinoid receptor agonist drastically increases its efficacy at the CB1 receptor

This study identifies a structural modification in a synthetic cannabinoid receptor agonist that significantly increases its efficacy at the CB1 receptor, with implications for monitoring illicit drug risks.

Fine-tuning GPCR-mediated neuromodulation by biasing signaling through different G-protein subunits

The paper shows how GINIP biases GPCR signaling to favor Gβγ over G signaling, preventing neurotransmission imbalances and seizure susceptibility.

Antiviral effect of candies containing persimmon-derived tannin against SARS-CoV-2 delta strain

This study shows that candies with persimmon-derived tannin reduce SARS-CoV-2 delta variant titers in saliva from healthy volunteers and patients with COVID-19.

Strand-biased circularizing integrative elements spread tmexCD-toprJ gene clusters encoding RND-type multidrug efflux pumps by repeated transpositions

The paper identifies a mobile genetic element, SE, that mediates the spread of tmexCD-toprJ gene clusters encoding RND-type multidrug efflux pumps through transposition in bacteria.

Unique genomic sequences in a novel Mycobacterium avium subsp. hominissuis lineage enable fine scale transmission route tracing during pig movement

This study identifies a novel Mycobacterium avium subsp. hominissuis lineage in pigs that enables transmission route tracing through unique genetic features.

Genome-wide association study reveals putative bacterial risk factors for cavitary Mycobacterium avium complex lung disease

This study identifies bacterial genetic variants associated with cavitary Mycobacterium avium complex lung disease using genome-wide association analysis of clinical isolates.

Atypical integrative element with strand-biased circularization activity assists interspecies antimicrobial resistance gene transfer from Vibrio alfacsensis

This study identifies a new type of mobile genetic element, SEs, that facilitates AMR gene transfer between marine bacteria by strand-biased circularization.

Genomic features of Mycobacterium avium subsp. hominissuis isolated from pigs in Japan.

The paper analyzes 30 draft genomes of Mycobacterium avium subsp. hominissuis from Japanese pigs to characterize their genomic features and potential virulence.

Genome-wide association study of gastric cancer- and duodenal ulcer-derived Helicobacter pylori strains reveals discriminatory amino acid differences and novel oncoprotein candidates

This study uses GWAS to identify genetic variations in H. pylori strains associated with gastric cancer and duodenal ulcers, revealing amino acid differences and novel oncoprotein candidates.

The effects of terminal tagging on homomeric interactions of the sigma 1 receptor

This study investigates how terminal tagging affects the oligomerization of the sigma 1 receptor using a modified Western blot protocol, revealing that the N-terminus influences ligand binding effects while the C-terminus is more suitable for modifications.

Inoculum size effects in blaIMP-6 and plasmid-mediated quinolone resistance gene-positive Enterobacteriaceae in Japan

This study examines resistance genes and inoculum size effects in IMP-6 MBL-producing Enterobacteriaceae with reduced susceptibility to fluoroquinolones and amikacin in Japan.

Emerging patterns of plasmid-host coevolution that stabilize antibiotic resistance

This study identifies common evolutionary mechanisms that stabilize antibiotic resistance plasmids across different host-plasmid pairs.