The structural basis for activation of voltage sensor domains in an ion channel TPC1
A. F. Kintzer, E. Green, P. Dominik, M. Bridges, J.-p. Armache, D. Deneka, S. Kim, W. Hubbell, A. Kossiakoff, Y. Cheng, R. Stroud
The paper presents four structures of the TPC1 ion channel's voltage sensor domain, revealing how activation occurs through conformational changes and Ca2+ binding.
bioRxiv · Jul 29, 2018Biophysics