Spatio-temporal Control of ERK Pulse Frequency Coordinates Fate Decisions during Mammary Acinar Morphogenesis
P. Ender, P. A. Gagliardi, M. Dobrzynski, A. Frismantiene, C. Dessauges, T. Höhener, M.-A. Jacques, A. R. Cohen, O. Pertz
The paper shows that ERK pulse frequency controls cell fate during mammary acinar morphogenesis, with high frequency promoting survival and low frequency inducing apoptosis.
bioRxiv · Nov 20, 2020Cell Biology