M. Dobrzynski

GTPase activating protein DLC1 spatio-temporally regulates Rho signaling

This study shows DLC1 regulates Rho activity levels globally and amplifies local Rho activity at focal adhesions under mechanical stress.

Automatic detection of spatio-temporal signalling patterns in cell collectives

The paper introduces ARCOS, a computational method to detect and quantify spatio-temporal signalling patterns in cell collectives, and demonstrates its application in identifying ERK activity waves in MCF10A cells.

Spatio-temporal Control of ERK Pulse Frequency Coordinates Fate Decisions during Mammary Acinar Morphogenesis

The paper shows that ERK pulse frequency controls cell fate during mammary acinar morphogenesis, with high frequency promoting survival and low frequency inducing apoptosis.

CODEX, a neural network approach to explore signaling dynamics landscapes

The paper introduces CODEX, a neural network method to analyze time-series signaling data and identify dynamic motifs in single-cell trajectories.

Collective ERK/Akt activity waves orchestrate epithelial homeostasis by driving apoptosis-induced survival

The paper shows ERK/Akt activity waves from apoptotic cells protect neighboring cells and maintain epithelial homeostasis through EGFR and MMP signaling.