Cell BiologybioRxiv
Regulation of astrocyte lipid metabolism and ApoE secretion by the microglial oxysterol, 25-hydroxycholesterol
A. G. CASHIKAR, D. T. Rios, D. Timm…·S. M. Paul
This study shows that 25-hydroxycholesterol from microglia alters astrocyte lipid metabolism and ApoE secretion through mechanisms involving LXRs, Abca1, and Cyp7b1.
DOI 10.1016/j.jlr.2023.100350