Regulation of astrocyte lipid metabolism and ApoE secretion by the microglial oxysterol, 25-hydroxycholesterol
A. G. CASHIKAR, D. T. Rios, D. Timm, J. Romero, J. Long, X. Han, D. Holtzman, S. M. Paul
This study shows that 25-hydroxycholesterol from microglia alters astrocyte lipid metabolism and ApoE secretion through mechanisms involving LXRs, Abca1, and Cyp7b1.
bioRxiv · May 3, 2022Cell Biology